The Regional Community of Baltimore has its roots in various foundations of Sisters of Mercy that began in the East and South in the 19th century.  In 1845, six Sisters of Charity of Our Lady of Mercy came from Charleston, South Carolina to Savannah, Georgia and opened St. Vincent's Academy.  In 1855, Mother Catherine Wynne accompanied by three sisters came from Pittsburgh, Pennsylvania to teach at St. Peter's School in Baltimore, Maryland.  Seven years later, four sisters opened St. Joseph's School and began ministering to the sick in Columbus, Georgia.  In 1876, the sisters moved their motherhouse, novitiate and boarding school to Macon, Georgia.  In 1877, Mother Mary Austin Carroll and a companion came from New Orleans and founded St. Michael's School in Pensacola, Florida.  Seven years later Convent of Mercy Academy was founded in Mobile, Alabama.

As early as1905, Pope Pius X encouraged the establishment of a general government for all Sisters of Mercy in the United States.  In 1929, forty formerly independent foundations joined to form the Sisters of Mercy of the Union.  The first Mother General was Sister Mary Carmelita Hartman, superior of the Baltimore Community.  In 1935, the geographic boundaries of the Province of Baltimore (Alabama, Florida, Georgia and Maryland) were established.

In 1991, the Sisters of Mercy of the Union and sixteen independent communities formed the Sisters of Mercy of the Americas.  The earlier geographic boundaries remain, now with the name Regional Community of Baltimore.  Today our sisters and associates continue Catherine McAuley's mission to serve persons who are poor, sick and uneducated.